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冠状动脉粥样硬化患者外周血Th17细胞与IL17的水平及意义
作者:王江凤高美华张娟来源:《医学信息》2019年第12期
摘要:目的探究冠状动脉粥样硬化患者外周血Th17细胞与IL17水平变化的意义。方法收集青岛阜外心血管病医院冠状动脉粥样硬化患者200例,根据疾病类型分为心肌梗死(AMI)组(52例)、不稳定型心绞痛(UA)组(68例)、稳定型心绞痛(SA)组(80例),另外选取同期200例体检者作为对照组。采用流式细胞术检测患者Th17细胞频率,ELISA法检测各组血清中IL17、CRP表达水平。结果流式细胞检测结果显示,与对照组比较,各组Th17细胞的频率表达均升高,差异具有统计学意义(P
关键词:冠状动脉粥样硬化Th17IL17CRP中图分类号:R5414文献标识码:ADOI:103969jiss
10061959201912020文章编号:10061959(2019)12006403Abstract:ObjectiveToi
vestigatethesig
ifica
ceofcha
gesi
Th17cellsa
dIL17levelsi
peripheralbloodofpatie
tswithcoro
aryatherosclerosisMethodsAtotalof200patie
tswithcoro
aryatherosclerosisweree
rolledi
Qi
gdaoFuwaiCardiovascularHospitalAccordi
gtothediseasetype,theyweredividedi
tomyocardiali
farctio
(AMI)group(52cases),u
stablea
gi
a(UA)group(68cases),stablea
gi
apectorisI
the(SA)group(80cases),
f龙源期刊网httpwwwqika
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a
other200physicalexami
atio
subjectswereselectedastheco
trolgroupThefreque
cyofTh17cellswasdetectedbyflowcytometryTheexpressio
levelsofIL17a
dCRPi
serumofeachgroupweredetectedbyELISAResultsTheresultsofflowcytometryshowedthatcomparedwiththeco
trolgroup,thefreque
cyofTh17cellsi
eachgroupi
creased,thediffere
cewasstatisticallysig
ifica
t(P005),a
dtheelevatedlevelofAMIgroupwashighertha
thatofSAgroupa
dUAgroup,thediffere
cewasstatisticallysig
ifica
t(P005)TheresultsofELISAshowedthatcomparedwiththeco
trolgroup,theexpressio
levelsofIL17a
dCRPi
creasedi
eachgroup,thediffere
cewasstatisticallysig
ifica
t(P005),a
dtheAMIgroupi
creasedThelevelwashighertha
thatofSAgroupa
dUAgroup,thediffere
cewasstatisticallysig
ifica
t(P005)Co
clusio
TheelevatedlevelsofTh17a
dIL17i
patie
tswithcoro
aryatherosclerosismayberespo
sibleforplatei
stabilityi
patie
tswithcoro
aryatherosclerosis
Keywords:Coro
aryatherosclerosisTh17IL17CRP
冠动脉粥样硬化病(coro
aryatherosclerosis)是一种慢性炎症性动脉硬化性疾病,世界范围内病死率较高,在中国其发病人数显著增加1。有研究发现T细胞参r
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