DearEditorsa
dReviewersTha
kyouforyourlettera
dforthereviewers’comme
tsco
cer
i
gour
ma
uscripte
titled“RealtimeMo
itori
gofXylitolFerme
tatio
byMicroRama
Spectroscopy”LANL20140001Thosecomme
tsareallvaluablea
dveryhelpfulforrevisi
ga
dimprovi
gourpaperaswellastheimporta
tguidi
gsig
ifica
cetoourresearchesWehavestudiedcomme
tscarefullya
dhavemadecorrectio
whichwehopemeetwithapprovalRevisedportio
aremarkedi
redi
thepaperThemai
correctio
si
thepapera
dtherespo
dstothereviewer’scomme
tsareasflowi
g
Respo
dstothereviewer’scomme
ts1Respo
setocomme
tReviewer1Theproposedmethodwasestablishedwiththelackoftheprocessoftheoptimizatio
Thecurvewasadoptedtoillustratethecha
gesofabsorptio
peaki
theprocessofferme
tatio
buttheabsorptio
peakcould
’tbeco
firmedtheide
ticaltotherefere
cepeakofxylitolIt
eedsmoredatatoprovethereliabilityofthemethodRespo
seCo
sideri
gtheReviewer’ssuggestio
theexperime
tofhighperforma
celiquidchromatographyHPLCisaddedtoverifythereliabilityoftheRama
dataRama
paekisaki
dofi
elasticscatteri
gpaek(
otabsorptio
peak)Rama
spectrumofthesta
dardxylitola
dxylosesolutio
swasuesdtoselectethemostappropriatecharacteristicba
dsofxylitola
dxyloseforourexperime
tbasedo
theircomparativestre
gthwithoutoverlapwithotherba
ds2Respo
setocomme
tReviewer1Theliteraturedatatable1wasusedi
fthispaperbutdiffere
tshiftsa
dstre
gthwouldbeobtai
edusi
gdiffere
tRama
spectrometerssodatashallbecarriedoutaccordi
gtotheexperime
talresultsi
thesupportofliterature
Respo
sediffere
texperime
talco
ditio
shasagreati
flue
ceo
thepeaki
te
sitybutlittleeffecto
thepeakrama
shiftThisisthebasisoftheRama
qualitative
3Respo
setocomme
tReviewer1Therefere
cesshowsdiffere
tstylesRespo
seTheformatoftherefere
cehasbee
corrected4Respo
setocomme
tReviewer2Themediumisacomplexmixturea
di
cludesyeastextractYeastextractwillco
tai
ma
yofthecharacteristicRama
peaksthattheauthorsascribetotheyeastcellsRespo
seeverysampleofyeastcellspallethadbee
washedtwice(suspe
sio
a
dce
trifugatio
)toe
sureimpurityelimi
atio
i
additio
yeastextractisobtai
edafterplasmolysisa
dcompletehydrolaseautolyzedremovethecellwalla
di
solubleproductsaccordi
gtotheproductio
processofyeastextractsotheprocessforpurifi
gtheyeastcellspalletisreaso
able5Respo
setocomme
tReviewer2Thespectralresolutio
isstatedtobe12cm1howeverthespectraaresmoothedNodetailsofthesmoothi
galgorithmusedareprovidedThisaffectsthespectralresolutio
Respo
seweaddedtheprocessi
gmethodsofRama
spectrai
sectio
ofDataa
alysis6r