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拜新同联合琥珀酸美托洛尔缓释片治疗顽固
性高血压的临床疗效观察
作者：蒋丹宇来源：《中国实用医药》2018年第04期
【摘要】目的探讨硝苯地平控释片（拜新同）联合琥珀酸美托洛尔缓释片治疗顽固性高血压的临床效果。方法120例顽固性高血压患者，随机分为实验组及对照组，各60例。实验组给予拜新同联合琥珀酸美托洛尔缓释片治疗，对照组单纯给予拜新同治疗。比较两组患者的降压治疗效果、不良反应发生情况及治疗前后的血压变化情况。结果治疗8周后，实验组总有效率为900，明显高于对照组的683，差异具有统计学意义（P005）；治疗8周后，实验组收缩压及舒张压均明显低于对照组，差异具有统计学意义（P
【关键词】硝苯地平控释片；琥珀酸美托洛尔缓释片；顽固性高血压；临床疗效
DOI：1014163jc
ki115547r201804001
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【Abstract】ObjectiveTodiscussthecli
icaleffectof
ifedipi
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【Keywords】Nifedipi
eco
trolledreleasetablets；Metoprololsustai
edreleasetablets；Refractoryhyperte
sio
；Cli
icalefficacy
f龙源期刊网httpwwwqika
comc
顽固性高血压是指已经使用了3种以上合适剂量降压药（其中包括利尿剂）联合治疗，血压仍未能达到目标水平14090mmHg（1mmHg0133kPa）以下，或者老年单纯收缩期高血压患者收缩压未降到160mmHg以下1。该病发病机制复杂，多种致病因素参与，同时也与患者个人体质及患者耐药性有一定关系2，r