Defi
itio
i
E
glishChapter1Structurea
dFu
ctio
ofProtei
s
1peptideu
it2motif3domai
4protei
de
aturatio
5pIoftheprotei
Peptideu
itThepartialdoublebo
dcharacterofthepeptidebo
dthatli
kstheCOOHcarbo
a
dtheNofa
amidemakesCα1CONHCα2sixatomscopla
arCα1a
dCα2aretra
s
toeachotherthesemirigidpla
ecomposedofthosesixatomsistermedaspeptideu
itAli
earseque
ceofami
oacidsresiduesli
kedtogetherbypeptidebo
dsMotifsaregroupi
gofseco
darystructuraleleme
tsthatfoldto
eareachotheri
spacea
dhavespecialfu
ctio
ssuchasααmotifβαβmotifzi
cfi
germotifSomemotifsco
sistofo
lyaegRGD
fewco
servedfu
ctio
allyimporta
tAAsrathertha
superseco
darystructuresArgGlyAspmotif
Domai
thetertiarystructureofsomeprotei
sca
bedividedi
too
eormorerelativelyi
depe
de
tcompactregio
sthatmaybejoi
edbyaflexiblesegme
tofthechai
thesecompactu
itscalleddomai
so
eprotei
mayco
tai
severaldomai
sthei
dividualdomai
shaveseparatefu
ctio
sProtei
de
aturatio
protei
spatialstructureisespeciallyse
sitivetode
aturi
gage
tshighTureastro
gacidsorbasesorga
icsolve
tsdeterge
tsheavymetalio
sTheseage
tsresulti
u
foldi
ga
ddisorga
izatio
ofprotei
spatialstructurewithoutcha
gei
primarystructurea
dassociatewithlossofbiologicalactivitypIoftheprotei
Protei
sareamphotericmoleculesco
tai
dissociati
ggroupsofoppositechargeCOOHNH2ate
dtermi
usa
dsidechai
sthe
etchargeofthesemoleculesi
solutio
depe
dso
thepH
etelectricchargepIisthepHatwhichprotei
molecularbecomeselectrically
eutralhas
o
Chapter2
E
zyme
1activesiteofe
zyme2isoe
zyme3zymoge
a
dactivatio
ofzymoge
4）Allosterice
zymesa
dallostericregulatio
ofe
zymese
zymesActivesiteofe
zymeisathreedime
sio
allocalregio
ofthee
zymetheregio
iscomposed5Covale
tmodificatio
of
ofseveralesse
tialgroupsofAAsthathasspecialspatialstructurewhichspecificallybi
ds
1
fsubstratea
dcatalyzesittobecomeproductCoe
zymesorprostheticgroupsca
bei
volvedi
theactivesiteIsozymesisoe
zymesareagroupofe
zymeswhichcatalyzethesamereactio
buthavediffere
tprotei
structurephysicochemicala
dimmu
ologicalpropertiesZymoge
ssomee
zymesaresy
thesizeda
dsecretedaslargei
activeprecursorscalledzymoge
sorproe
zymesZymoge
sareactivatedbytheirreversiblehydrolysiso
eormorepeptidebo
dsa
dformi
gorexposi
gtheactivesitei
thee
zymemoleculeAllosterice
zymethelargee
zymewhoseactivityca
bemodulatedi
theprese
ceofallostericeffectorata
allostericsiteTheallostericbi
di
gsitea
dcatalyticsitearedisti
cta
dseparatedspatiallyo
e
zymea
dthee
zymeactivityca
beregulatedeitherpositivelyor
egativer