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　目的探讨血清肿瘤标志物在肺癌患者中的水平变化及诊断意义。方法采用RocheElecsys2016电化学发光全自动免疫分析仪检测肺癌组、肺良性病变组和健康体检组的血清标本中癌胚抗原CEA、肿瘤相关抗原CA125和神经原特异度烯醇化酶NSE的表达，并将这三组血清标本中CEA、CA125和NSE表达的检测结果进行分析。结果肺癌组血清中的CEA、CA125和NSE的水平均明显高于其他两组，差异有统计学意义P005肺良性病变组及健康体检组比较差异无统计学意义P005CEA和NSE表达水平分别在肺腺癌和小细胞癌中高于其他两组，差异有统计学意义P005CA125的表达水平在三组中比较差异无统计学意义P005CEA的灵敏度和特异度分别为4656和9631，高于其他两项指标。结论CEA、CA125和NSE的表达与肺癌的发生和发展密切相关，且CEA和NSE分别在肺腺癌和小细胞癌中表达较高，CEA灵敏度和特异度较高，为进一步研究肺癌提供参考价值。r
　　关键词血清肿瘤标志物癌胚抗原肿瘤相关抗原神经原特异度烯醇化酶肺癌水平变化诊断意义r
　　中图分类R7342文献标识码A编16744721201609b013703r
　　AbstractObjectiveToi
vestigatethelevelcha
gesa
ditsdiag
osticsig
ifica
ceofserumtumormarkersi
patie
tswithlu
gca
certhodsTheexpressio
ofNSE，CA125a
dCEAi
theserumsamplesoflu
gca
cergroup，lu
gca
cergroupa
dhealthyco
trolgroupweredetectedbyRocheElecsys2016electrochemicallumi
esce
ceimmu
oassay，thedetectio
resultsofCEA，CA125a
dNSEexpressio
i
threegroupsofserumsampleswerea
alyzedResultsThelevelsofserumCEA，CA125a
dNSEi
lu
gca
cergroupweresig
ifica
tlyhighertha
theothertwogroups，a
dthediffere
cewasstatisticallysig
ifica
tP005Therewere
osig
ifica
tdiffere
cebetwee
be
ig
lu
gdiseasegroupa
dhealthyco
trolgroupP005Theexpressio
levelsofCEAa
dNSEi
lu
gade
ocarci
omaa
dsmallcellcarci
omawerehighertha
theothertwogroups，thediffere
ceswerestatisticallysig
ifica
tP005Therewas
osig
ifica
tdiffere
cei
theexpressio
levelofCA125betwee
thethreegroupsP005These
sitivitya
dspecificityofCEAwas4656a
d9631，highertha
theothertwoi
dicatorsCo
clusio
Theexpressio
ofCEA，CA125a
dNSEiscloselyrelatedtotheoccurre
cea
ddevelopme
toflu
gca
cerTheexpressio
ofCEAa
dNSEi
lu
gade
ocarci
omaa
dsmallcellcarci
omaarehigher，a
dthese
sitivitya
dspecificityofCEAarehigherItca
providearefere
cevalueforthefurtherstudyoflu
gca
cerr
　　KeywordsSerumtumormarkersCEACA125NSELu
gca
cerLevelcha
geDiag
osticsig
ifica
cer
　　肺癌是严重威胁全球人类健康的恶性肿瘤之一，近年来随着人们生活环境和习惯的改变，死亡率呈逐年上升的趋势。r