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血清补体H因子水平与IgA肾病病理、临床表现及预后的关系
作者：林叶春彭鲲来源：《健康必读下旬刊》2018年第01期
【摘要】目的：分析血清补体H因子（CFH）水平与IgA肾病（IgAN）病理、临床表现及预后的关系。方法：我院2014年1月至2015年12月收治的80例IgAN患者，均于肾脏穿刺当日采集空腹静脉血，检测血清CFH水平，并根据CFH水平分为低水平组（
35，CFH【关键词】IgAN；补体；CFH；病理；预后AbstractObjective：Toa
alyzetherelatio
shipbetwee
thelevelofserumcompleme
tfactorH（CFH）a
dpathology，cli
icalma
ifestatio
sa
dprog
osisofIgA
ephropathy（IgAN）Methods：80casesofpatie
tswithIgANtreatedi
ourhospitalfromJa
uary2013toJa
uary2015weree
rolledi
thestudyTheirfasti
gve
ousbloodwascollectedtodetectserumCFHlevelo
thedayofre
albiopsyAccordi
gtotheCFHlevel，thepatie
tsweredividedi
tolowlevelgroup（
35，CFHlevel300ugL）a
dlowerlevelgroup（
45，CFHlevelof300～380ugL）Thebaseli
edata，cli
icalma
ifestatio
s，laboratoryfi
di
gsa
dpathologicalfeaturesofthetwogroupswerecollecteda
da
alyzed，a
dbothtwogroupswerefollowedupforatleast2yearsResults：Therewas
osig
ifica
tdiffere
cebetwee
thetwogroupsi
baseli
edata（P005）Theserumcreati
i
e，blooduricacida
d24huri
eprotei
qua
titatio
weresig
ifica
tlyhigheri
thelowlevelgrouptha
thelowerlevelgroup，a
dlevelsofIgAa
dC3weresig
ifica
tlylowertha
thelowerlevelgroup（P005）TheLeespathologicalgrade，Oxfordtypea
dtheseverityofsmallarterylesio
sshowedstatisticallysig
ifica
tdiffere
cesbetwee
thetwogroups（P005）Thediseaseprogressio
ratesi
thelowlevelgroupa
dlowerlevelgroupduri
gthefollowupperiodwere2000（735）a
d444（245），respectivelyKapla
Meiersurvivala
alysisshowedthattheprogressio
freetimeoflowlevelgroupwassig
ifica
tlyshortertha
thatoflowerlevelgroup（5590±187）mo
thsvs（6010±178）mo
ths（P005）U
ivariateCoxregressio
a
alysisshowedthatserumCFHlevelwasariskfactorfortheprog
osisofpatie
tswithIgAN（P005）Co
clusio
：SerumCFHleveliscloselyrelatedtopathology，cli
icalma
ifestatio
sa
dprog
osisofIgANAb
ormaldecreaseofCFHleveli
dicatesthatthepatie
tsco
ditio
isseriousa
dtheprog
osisispoorKeywords：IgAN；Compleme
t；CFH；Pathology；Prog
osis【中图分类号】R7952【文献标识码】B【文章编号】16723783（2018）010301
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comc
IgA肾病（IgA
ephropathy，IgAN）是最常见的原发性肾小球肾炎，在我国约占全部原发性肾小球肾炎的45，大多数患者呈r