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(英文摘要尽量用过去时和被动语态;坚决不能用在线翻译)加黑)Keywords小五(小五TimesNewRoma
加黑)ApoptosisFasFasLExpressio
ofapoptosisge
eImmu
ohistochemistryImmu
ity加黑orga
Gushichicke
(关键词要用实词,小五TimesNewRoma
,首字母均应大写,关键词之间用“”号隔开)
(四号楷体空行)
细胞凋亡(正文用五号宋体)是生物界广泛存在的一种重要的生命过程,是多细胞动物为调节机体发育、维护内环境稳定、有基因调控的细胞主动性死亡过程。Fas与Apo1是同一种跨膜糖蛋白分子,在结构和功能上属于肿瘤坏死因子(TZFtumor
ecrosisfactor)(正文英文五号TimesNewRoma
格式)受体和神经生长因子受体(NGFR
ervegrowthfactorreceptor)的家族成员,它与细胞上的某些分子FasL交联可诱导细胞凋亡的发生。FasL(Fasliga
d)是Fas的配体(Fas是FasL的受体)。FasL主要在被激活的T细胞和B细胞上表达。当Fas抗原和FasL结合后,可以诱发Fas表达,细胞发生凋亡。Fas和FasL在免疫系统细胞上的表达相对较高,其介导的细胞凋亡在淋巴细胞的发育和凋亡中发挥重要作用12(参考文献用顺序著录法,文献序号上标)。Fas系统功能正常对机体自身稳定具有重要作用,Fas功能过强或缺陷均可导致疾病发生2。前人对Fas和FasL在许多器官内的表达及其意义均有r