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纳米碳与吲哚菁绿荧光导航联合在乳腺癌前
哨淋巴结活检中的应用价值探讨
作者:李晓坚周丹来源:《中国医学创新》2017年第11期
【摘要】目的:研究纳米碳与吲哚菁绿(ICG)荧光导航联合在乳腺癌前哨淋巴结(SLN)活检中的应用价值。方法:选取2015年6月2016年12月本院收治的临床腋窝淋巴结阴性乳腺癌患者122例,根据随机数字表法将其分为观察组与对照组,各61例。对照组行ICG示踪,观察组行纳米碳联合ICG示踪。两组患者均行前哨淋巴结活检术,并将手术切除的前哨淋巴结进行术中冰冻与常规石蜡以及免疫组织化学病理检查。结果:观察组检出率及平均检出数量均显著高于对照组(P005)。观察组转移SLN检出率略高于对照组,但差异无统计学意义(P005)。年龄、临床分期、原发肿瘤部位、注射部位不同患者的检出率对比,差异均无统计学意义(P005)。结论:纳米碳联合ICG示踪应用于乳腺癌前哨淋巴结活检术中,可有效提高SLN检出率与检出数量,有利于降低漏诊率与误诊率。
【关键词】乳腺癌;前哨淋巴结;纳米碳;吲哚菁绿;活检
Applicatio
ValueofNa
oCarbo
Combi
edwithI
docya
i
eGree
Fluoresce
ceNavigatio
i
theSe
ti
elLymphNodeBiopsyofBreastCa
cerLIXiaojia
,ZHOUDa
MedicalI
ovatio
ofChi
a,2017,14(11):090093
【Abstract】Objective:Tostudythe
a
ometercarbo
a
di
docya
i
egree
(ICG),fluoresce
ce
avigatio
joi
ti
theapplicatio
ofse
ti
ellymph
odes(SLNS)detectedbiopsyofbreastca
cerMethod:FromJu
e2015toDecember2016,122casesofaxillarylymph
ode
egativebreastca
cerpatie
tswereselectedAccordi
gtora
dom
umbertablemethodtheyweredividedi
totheobservatio
groupa
dtheco
trolgroup,61casesi
eachgroupTheco
trolgroupwasgive
ICGtracer,theobservatio
groupwasgive
Li
eNa
oCarbo
joi
tICGtracer,twogroupsofpatie
tswereli
esofse
ti
ellymph
odebiopsya
dsurgicalremovalofse
ti
ellymph
odewithi
traoperativefroze
withco
ve
tio
alparaffi
a
dimmu
ohistochemicalpathologicexami
atio
Result:Theobservatio
group’sdetectio
ratea
dtheaverage
umberofdetectio
weresig
ifica
tlyhighertha
thoseoftheco
trolgroup(P005)Theobservatio
group’stra
sferSLNSdetectio
ratedetectedslightlyhighertha
thatoftheco
trolgroup(P005)Age,cli
icalstage,theprimarytumorsite,atthei
jectio
sitedetectio
ratei
patie
tswithdiffere
tco
trastwere
otobvious(P005)Co
clusio
:Na
oCarbo
joi
tICGtracerusedi
breastca
cerse
ti
ellymph
odebiopsy,whichca
effectivelyimproveSLNSdetectio
ratea
ddetectio
qua
titydetected,ishelpfultodecreasethemisseddiag
osisa
dmisdr