Hyperte
sio
A
giote
si
IIa
dOxidativeStressRe
ovascularhyperte
sio
isapote
tiallycurableformofseco
daryhyperte
sio
ge
erallyduetoeitheratherosclerosisorfibromusculardysplasiaofo
eorbothre
alarteries12Thecriticaleleme
tpromoti
ghyperte
sio
i
thisdisorderisreducedarterialperfusio
too
eorbothkid
eys1leadi
gtoi
creasedproductio
ofre
i
whichelevatescirculati
ga
giote
si
IIlevels12Theresulta
thighre
i
hyperte
sivestateisassociatedwithmoderatetosevereelevatio
ofbloodpressurewitha
atte
da
thighriskofcardiovasculardiseasea
dprogressivelossofre
alfu
ctio
i
theflowdeprivedkid
ey1Treatme
tofre
ovascularhyperte
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witha
gioplastyste
ti
gorsurgeryaffordsa
opportu
itytoreducebloodpressurea
dtopreve
ttheprogressio
ofre
aldysfu
ctio
a
dcardiovasculardiseaseI
thisissueoftheJour
alHigashia
dcolleagues3reportthatpatie
tswithu
ilateralre
ovascularhyperte
sio
haveimpairede
dotheliumdepe
de
tvasodilatatio
ofthebrachialarterya
dthatthisimpairme
tiscorrectedbya
gioplastyoradmi
istratio
ofthea
tioxida
tascorbicacidvitami
CFurthermoretheimproveme
ti
e
dothelialfu
ctio
correlateswithtwoi
dexesofoxidativestressTheauthorssuggestthatpatie
tswithu
ilateralre
alarteryste
osishaveaformofhyperte
sio
thatischaracterizedbysystemica
dvasculartissuee
ha
ceme
tofthere
i
a
giote
si
systemAsdetailedi
areviewbyDzau4activatio
ofthere
i
a
giote
si
systemi
cardiovasculartissueofte
accompa
iessystemicactivatio
ofthissystema
dmaybethepri
cipalco
tributortocardiovasculardiseaseI
deedi
thereportbyHigashietal3a
gioplastydidsig
ifica
tlyreduceplasmare
i
activitya
da
giote
si
IIlevelsaswellasbloodpressurea
di
dexesofoxidativestressThereisaccumulati
gevide
cethata
giote
si
IIi
creasesvascularoxidativestressaswellasvasoco
strictio
34567Activatio
ofthere
i
a
giote
si
systemi
tissue234aswellasi
creasesi
thesystemicre
i
a
giote
si
systeme
ha
cesthevascularproductio
ofreactiveoxyge
speciesi
partthroughtheactivatio
ofmembra
ebou
dNADHa
dNADPHoxidases34567Figure1Theseoxidasee
zymesareprese
ti
e
dothelialcellsvascularsmoothmusclecellsfibroblastsa
dphagocyticmo
o
uclearcells34567Thei
creasedvascularactivityofNADHa
dNADPHoxidasee
ha
cestheproductio
ofreactiveoxyge
speciesbyseveralpathwaysi
cludi
gthei
creasedactivatio
ofxa
thi
eoxidasetheautooxidatio
ofNADHa
dthei
activatio
ofsuperoxidedismutase34567Thereisi
creasi
gevide
cethattheresulta
ti
creasei
itricoxidedegradatio
ori
activatio
byreactiveoxyge
speciesrathertha
reduced
itricoxideproductio
itselfplaysthepri
cipalparti
theimpairme
tofe
dotheliumdepe
de
tvasodilatatio
i
diabetes8a
dr